Are you old and bald

Are you old and bald? Scientific research says hair loss is expected to reverse

Researchers at New York University School of Medicine said they found a way to reverse the baldness process and successfully re-grow the damaged skin. They activated the "sonic hedgehog" signaling pathway in the brain. This signaling pathway is very active when the embryo develops in the uterus and the hair follicle begins to form. However, in aging or damaged skin, this pathway is blocked.

The data shows that a quarter of men will become bald when they reach the age of 25, and Prince William of England has shown signs of baldness at the age of 22. Baldness also exists in women. According to the American Academy of Dermatology, 40% of women will have obvious hair loss problems when they reach the age of 40.

The study analyzed the damaged skin of laboratory mice, focusing on fibroblasts that secrete collagen. Collagen is a protein that is closely related to the shape and strength of skin and hair. In addition, as far as scientists know, fibroblasts can also play a guiding role in some of the physiological processes involved in tissue healing.

Led by Dr. Mayumi Ito, the team activated the sonic hedgehog signaling pathway in mice, the pathway that cells use to communicate with each other. By promoting cell-to-cell communication, the mice re-grow their hair within four weeks. After nine weeks, hair roots and hair shafts began to form.

Scientists have previously assumed that scar tissue and collagen accumulation are responsible for the inability of the damaged skin to grow. But this study provides a new way for scientists.

Dr. Mayumi Ito said: "Now we find that this is actually related to cell signaling. This signal transmission was once very active during embryonic development, but as we get older, the process is less active in mature skin. Our results show that stimulation of fibroblasts through the sonic hedgehog signaling pathway stimulates hair growth, which we have never observed before in wound healing."

Dr. Mayumi Ito pointed out that because of the number of patients with disfigurement caused by trauma, burns and other injuries, it is a major appeal in the medical community to make the damaged skin grow again, but it has not been solved. This new discovery not only helps hair grow on damaged skin, it may also promote hair growth on mature skin. In addition, the discovery may also help us find better drugs that restore hair growth.

There are other experiments that attempt to open the sonic hedgehog pathway, but often lead to a higher risk of cancer. To circumvent these risks, Dr. Mayumi Ito's team activated only the fibroblasts that clung to the underside of the epidermis, Hair Transplant In Islamabad where the roots of the hair follicles were located. The experimental results were very successful. Therefore, Dr. Mayumi Ito believes that this obstacle is hopeful to be broken, and we are one step closer to achieving damaged skin regeneration.

Doctors hope to find medicines that are designed to promote hair regeneration. However, the drugs currently approved have certain side effects hair Transplant. For example, there is an open-frame product called Minoxidil that is foamed or emulsified and can be applied to the scalp. It nourishes hair follicles by promoting blood flow to the scalp. About two-thirds of the users have successfully grown their hair. But minoxidil also has a lot of side effects, such as rapid heartbeat, swelling of the feet, stomach pain and so on. There is also a drug for men: finasteride. It inhibits an enzyme that converts testosterone to dioxotestosterone, which is one of the culprit in promoting hair loss. Studies have shown that about 80% of male patients are willing to grow some hair after using this drug. However, one in 60 people have infertility, and the longer they take, the higher the risk of infertility.